Growth inhibition and apoptosis induced by daunomycin-conjugated triplex-forming oligonucleotides targeting the c-myc gene in prostate cancer cells

Covalent attachment of intercalating agents to triplex-forming oligonucleotides (TFOs) is a promising strategy to enhance triplex stability and biological activity. We have explored the possibility to use the anticancer drug daunomycin as triplex stabilizing agent. Daunomycin-conjugated TFOs (dauno-...

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Detalles Bibliográficos
Autores principales: Napoli, Sara, Negri, Umberto, Arcamone, Federico, Capobianco, Massimo L., Carbone, Giuseppina M., Catapano, Carlo V.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356532/
https://www.ncbi.nlm.nih.gov/pubmed/16449206
http://dx.doi.org/10.1093/nar/gkj473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356532/
https://www.ncbi.nlm.nih.gov/pubmed/16449206
http://dx.doi.org/10.1093/nar/gkj473

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