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Therapeutic protein transduction of mammalian cells and mice by nucleic acid-free lentiviral nanoparticles
The straightforward production and dose-controlled administration of protein therapeutics remain major challenges for the biopharmaceutical manufacturing and gene therapy communities. Transgenes linked to HIV-1-derived vpr and pol-based protease cleavage (PC) sequences were co-produced as chimeric f...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356536/ https://www.ncbi.nlm.nih.gov/pubmed/16449199 http://dx.doi.org/10.1093/nar/gnj014 |