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Influence of advanced age of maternal grandmothers on Down syndrome

BACKGROUND: Down syndrome (DS) is the most common chromosomal anomaly associated with mental retardation. This is due to the occurrence of free trisomy 21 (92–95%), mosaic trisomy 21 (2–4%) and translocation (3–4%). Advanced maternal age is a well documented risk factor for maternal meiotic nondisju...

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Detalles Bibliográficos
Autores principales: Malini, Suttur S, Ramachandra, Nallur B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360060/
https://www.ncbi.nlm.nih.gov/pubmed/16412239
http://dx.doi.org/10.1186/1471-2350-7-4