Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A

The deacetylase inhibitor Trichostatin A (TSA) induces the transcription of the Major Histocompatibility Class II (MHC II) DRA gene in a way independent of the master coactivator CIITA. To analyze the molecular mechanisms by which this epigenetic regulator stimulates MHC II expression, we used chrom...

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Detalles Bibliográficos
Autores principales: Gialitakis, Manolis, Kretsovali, Androniki, Spilianakis, Charalampos, Kravariti, Lara, Mages, Jörg, Hoffmann, Reinhard, Hatzopoulos, Antonis K., Papamatheakis, Joseph
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360741/
https://www.ncbi.nlm.nih.gov/pubmed/16452299
http://dx.doi.org/10.1093/nar/gkj462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360741/
https://www.ncbi.nlm.nih.gov/pubmed/16452299
http://dx.doi.org/10.1093/nar/gkj462

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