Haploinsufficiency of the Mus81–Eme1 endonuclease activates the intra-S-phase and G(2)/M checkpoints and promotes rereplication in human cells

The Mus81–Eme1 complex is a structure-specific endonuclease that preferentially cleaves nicked Holliday junctions, 3′-flap structures and aberrant replication fork structures. Mus81(−/−) mice have been shown to exhibit spontaneous chromosomal aberrations and, in one of two models, a predisposition t...

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Detalles Bibliográficos
Autores principales: Hiyama, Takashi, Katsura, Mari, Yoshihara, Takashi, Ishida, Mari, Kinomura, Aiko, Tonda, Tetsuji, Asahara, Toshimasa, Miyagawa, Kiyoshi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360746/
https://www.ncbi.nlm.nih.gov/pubmed/16456034
http://dx.doi.org/10.1093/nar/gkj495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360746/
https://www.ncbi.nlm.nih.gov/pubmed/16456034
http://dx.doi.org/10.1093/nar/gkj495

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