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Haploinsufficiency of the Mus81–Eme1 endonuclease activates the intra-S-phase and G(2)/M checkpoints and promotes rereplication in human cells
The Mus81–Eme1 complex is a structure-specific endonuclease that preferentially cleaves nicked Holliday junctions, 3′-flap structures and aberrant replication fork structures. Mus81(−/−) mice have been shown to exhibit spontaneous chromosomal aberrations and, in one of two models, a predisposition t...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360746/ https://www.ncbi.nlm.nih.gov/pubmed/16456034 http://dx.doi.org/10.1093/nar/gkj495 |