Permissive Transcriptional Activity at the Centromere through Pockets of DNA Hypomethylation

DNA methylation is a hallmark of transcriptional silencing, yet transcription has been reported at the centromere. To address this apparent paradox, we employed a fully sequence-defined ectopic human centromere (or neocentromere) to investigate the relationship between DNA methylation and transcript...

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Detalles Bibliográficos
Autores principales: Wong, Nicholas C, Wong, Lee H, Quach, Julie M, Canham, Paul, Craig, Jeffrey M, Song, Jenny Z, Clark, Susan J, Choo, K. H. Andy
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361766/
https://www.ncbi.nlm.nih.gov/pubmed/16477312
http://dx.doi.org/10.1371/journal.pgen.0020017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361766/
https://www.ncbi.nlm.nih.gov/pubmed/16477312
http://dx.doi.org/10.1371/journal.pgen.0020017

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