p16(INK4a) Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells

Aneuploidy, frequently observed in premalignant lesions, disrupts gene dosage and contributes to neoplastic progression. Theodor Boveri hypothesized nearly 100 years ago that aneuploidy was due to an increase in centrosome number (multipolar mitoses) and the resultant abnormal segregation of chromos...

Descripción completa

Detalles Bibliográficos
Autores principales: McDermott, Kimberly M, Zhang, Jianmin, Holst, Charles R, Kozakiewicz, B. Krystyna, Singla, Veena, Tlsty, Thea D
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361797/
https://www.ncbi.nlm.nih.gov/pubmed/16464125
http://dx.doi.org/10.1371/journal.pbio.0040051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361797/
https://www.ncbi.nlm.nih.gov/pubmed/16464125
http://dx.doi.org/10.1371/journal.pbio.0040051

Ejemplares similares