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p16(INK4a) Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells
Aneuploidy, frequently observed in premalignant lesions, disrupts gene dosage and contributes to neoplastic progression. Theodor Boveri hypothesized nearly 100 years ago that aneuploidy was due to an increase in centrosome number (multipolar mitoses) and the resultant abnormal segregation of chromos...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361797/ https://www.ncbi.nlm.nih.gov/pubmed/16464125 http://dx.doi.org/10.1371/journal.pbio.0040051 |