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Diels-Alder cycloadditions in water for the straightforward preparation of peptide–oligonucleotide conjugates
The Diels-Alder reaction between diene-modified oligonucleotides and maleimide-derivatized peptides afforded peptide–oligonucleotide conjugates with high purity and yield. Synthesis of the reagents was easily accomplished by on-column derivatization of the corresponding peptides and oligonucleotides...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1369286/ https://www.ncbi.nlm.nih.gov/pubmed/16478710 http://dx.doi.org/10.1093/nar/gnj020 |