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Diels-Alder cycloadditions in water for the straightforward preparation of peptide–oligonucleotide conjugates

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The Diels-Alder reaction between diene-modified oligonucleotides and maleimide-derivatized peptides afforded peptide–oligonucleotide conjugates with high purity and yield. Synthesis of the reagents was easily accomplished by on-column derivatization of the corresponding peptides and oligonucleotides...

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Detalles Bibliográficos
Autores principales:	Marchán, Vicente, Ortega, Samuel, Pulido, Daniel, Pedroso, Enrique, Grandas, Anna
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1369286/ https://www.ncbi.nlm.nih.gov/pubmed/16478710 http://dx.doi.org/10.1093/nar/gnj020

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