Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat

BACKGROUND: The angiotensin-converting enzyme (ACE) inhibitors have complicated and poorly characterized pharmacokinetics. There are two binding sites per ACE (high affinity "C", lower affinity "N") that have sub-nanomolar affinities and dissociation rates of hours. Most inhibito...

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Detalles Bibliográficos
Autores principales: Levitt, David G, Schoemaker, Rik C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1373666/
https://www.ncbi.nlm.nih.gov/pubmed/16398929
http://dx.doi.org/10.1186/1472-6904-6-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1373666/
https://www.ncbi.nlm.nih.gov/pubmed/16398929
http://dx.doi.org/10.1186/1472-6904-6-1

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