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Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat
BACKGROUND: The angiotensin-converting enzyme (ACE) inhibitors have complicated and poorly characterized pharmacokinetics. There are two binding sites per ACE (high affinity "C", lower affinity "N") that have sub-nanomolar affinities and dissociation rates of hours. Most inhibito...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1373666/ https://www.ncbi.nlm.nih.gov/pubmed/16398929 http://dx.doi.org/10.1186/1472-6904-6-1 |