The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

BACKGROUND: Huntington's disease (HD) pathogenesis is due to an expanded polyglutamine tract in huntingtin, but the specificity of neuronal loss compared with other polyglutamine disorders also implies a role for the protein's unknown inherent function. Huntingtin is moderately conserved,...

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Detalles Bibliográficos
Autores principales: Takano, Hiroki, Gusella, James F
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137586/
https://www.ncbi.nlm.nih.gov/pubmed/12379151
http://dx.doi.org/10.1186/1471-2202-3-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137586/
https://www.ncbi.nlm.nih.gov/pubmed/12379151
http://dx.doi.org/10.1186/1471-2202-3-15

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