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Sequential boundaries approach in clinical trials with unequal allocation ratios
BACKGROUND: In clinical trials, both unequal randomization design and sequential analyses have ethical and economic advantages. In the single-stage-design (SSD), however, if the sample size is not adjusted based on unequal randomization, the power of the trial will decrease, whereas with sequential...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1382245/ https://www.ncbi.nlm.nih.gov/pubmed/16412232 http://dx.doi.org/10.1186/1471-2288-6-1 |