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Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase
DNA methyltransferase 1 (Dnmt1) has a central role in copying the pattern of DNA methylation after replication which is one manifestation of epigenetic inheritance. With oligonculeotide substrates we show that mouse Dnmt1 has a 30- to 40-fold preference for hemimethylated DNA that is almost lost aft...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383621/ https://www.ncbi.nlm.nih.gov/pubmed/16500889 http://dx.doi.org/10.1093/nar/gkl002 |