Alkylation of template strand of coding region causes effective gene silencing

We recently developed a new type of pyrrole (Py)–imidazole (Im) polyamide–tetrahydrocyclopropabenzindolone (CBI) conjugate with an indole linker as a stable sequence-specific alkylating agent. In this study, we investigated the gene silencing activities of polyamides A, B and C, which selectively al...

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Detalles Bibliográficos
Autores principales: Shinohara, Ken-ichi, Sasaki, Shunta, Minoshima, Masafumi, Bando, Toshikazu, Sugiyama, Hiroshi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383623/
https://www.ncbi.nlm.nih.gov/pubmed/16500890
http://dx.doi.org/10.1093/nar/gkl005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383623/
https://www.ncbi.nlm.nih.gov/pubmed/16500890
http://dx.doi.org/10.1093/nar/gkl005

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