Cargando…

Role of BRCA gene dysfunction in breast and ovarian cancer predisposition

Tumor suppressor genes that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are mutated in the germline. The two major hereditary breast/ovarian cancer predisposition genes, BRCA1 and BRCA2, appear to participate in a common...

Descripción completa

Detalles Bibliográficos
Autor principal:	Scully, Ralph
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2000
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138653/ https://www.ncbi.nlm.nih.gov/pubmed/11250724 http://dx.doi.org/10.1186/bcr76

Ejemplares similares

Non-Coding Variants in BRCA1 and BRCA2 Genes: Potential Impact on Breast and Ovarian Cancer Predisposition
por: Santana dos Santos, Elizabeth, et al.
Publicado: (2018)

How many more breast cancer predisposition genes are there?
por: Easton, Douglas F
Publicado: (1999)

MSH2 is the very young onset ovarian cancer predisposition gene, not BRCA1
por: Flaum, Nicola, et al.
Publicado: (2023)

The pathogenic role of the BRCA2 c.7847C>T (p.Ser2616Phe) variant in breast and ovarian cancer predisposition
por: Yamazawa, Kazuki, et al.
Publicado: (2023)

The frequency of cancer predisposition gene mutations in hereditary breast and ovarian cancer patients in Taiwan: From BRCA1/2 to multi-gene panels
por: Sung, Pi-Lin, et al.
Publicado: (2017)

Variation in breast cancer risk in BRCA1 and BRCA2 mutation carriers
por: Rebbeck, Timothy R, et al.
Publicado: (2008)

Are BRCA1- and BRCA2-related breast cancers associated with increased mortality?
por: Gareth Evans, D, et al.
Publicado: (2004)

The association between gene SNPs and cancer predisposition: Correlation or causality?
por: Tan, Hua
Publicado: (2017)

Epistatic Relationships in the BRCA1-BRCA2 Pathway
por: Scully, Ralph
Publicado: (2011)

Relationship between MUTYH, OGG1 and BRCA1 mutations and mRNA expression in breast and ovarian cancer predisposition
por: Moscatello, Carmelo, et al.
Publicado: (2021)

Chromosomal instability and cancer predisposition: insights from studies on the breast cancer susceptibility gene BRCA2
por: Venkitaraman, A
Publicado: (2001)

Segregation analysis of the BRCA2 c.9227G>T variant in multiple families suggests a pathogenic role in breast and ovarian cancer predisposition
por: Agata, Simona, et al.
Publicado: (2020)

Melanoma predisposition—A limited role for germline BRCA1 and BRCA2 variants
por: Adams, David J., et al.
Publicado: (2019)

BRCA1 promoter methylation in peripheral blood cells and predisposition to breast cancer
por: Al-Moghrabi, Nisreen M.
Publicado: (2017)

Looking for BRCA1 and BRCA2 mutations in Asian women with breast cancer
por: Narod, Steven A.
Publicado: (2023)

Principles of genetic predisposition to malignancies
por: Dębniak, Tadeusz, et al.
Publicado: (2008)

Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?
por: McAllister, Kimberly A, et al.
Publicado: (2002)

Genetic Predisposition to Breast and Ovarian Cancers: How Many and Which Genes to Test?
por: Angeli, Davide, et al.
Publicado: (2020)

Redefining and expanding the sphere of influence of BRCA in breast and colorectal cancers and beyond
por: Lou, Emil
Publicado: (2022)

Universal Tumor DNA BRCA1/2 Testing of Ovarian Cancer: Prescreening PARPi Treatment and Genetic Predisposition
por: Vos, Janet R, et al.
Publicado: (2019)

Epithelial Ovarian Cancer: Providing Evidence of Predisposition Genes
por: Shah, Sidrah, et al.
Publicado: (2022)

A protective role for BRCA2 at stalled replication forks
por: Chandramouly, Gurushankar, et al.
Publicado: (2011)

Breast cancer therapy for BRCA1 carriers: moving towards platinum standard?
por: Imyanitov, Evgeny N
Publicado: (2009)

Discussion on the use of taxanes for treatment of breast cancers in BRCA1 mutations carriers
Publicado: (2007)

RANKL/OPG in Breast Cancer — Extending Its Territory to BRCA Mutation Carriers
por: Rachner, Tilman D., et al.
Publicado: (2015)

Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer
por: Kalachand, Roshni D., et al.
Publicado: (2020)

The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancer
por: McCoy, Marcia L, et al.
Publicado: (2003)

Phase 1 trial of olaparib and oral cyclophosphamide in BRCA breast cancer, recurrent BRCA ovarian cancer, non-BRCA triple-negative breast cancer, and non-BRCA ovarian cancer
por: Lee, Chee Khoon, et al.
Publicado: (2019)

Methylation of BRCA1 promoter in sporadic breast cancer
por: Jagtap, Sunil Vitthalrao, et al.
Publicado: (2023)

An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA)
por: Chenevix-Trench, Georgia, et al.
Publicado: (2007)

Diabetes predisposition inherited through maternal germline
por: Zhu, Hong, et al.
Publicado: (2022)

Identification of Novel BRCA1 and RAD50 Mutations Associated With Breast Cancer Predisposition in Tunisian Patients
por: Mighri, Najah, et al.
Publicado: (2020)

Diagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation
por: Ribeiro Guerra, Maximiliano, et al.
Publicado: (2021)

Mutational Analysis of BRCA1 Gene in Ovarian and Breast‐ovarian Cancer Families in Japan
por: Takano, Masashi, et al.
Publicado: (1997)

The role of BRCA1/2 in hereditary and familial breast and ovarian cancers
por: Hawsawi, Yousef M., et al.
Publicado: (2019)

Five recurrent BRCA1/2 mutations are responsible for cancer predisposition in the majority of Slovenian breast cancer families
por: Krajc, Mateja, et al.
Publicado: (2008)

Molecular analysis of the BRCA1 and BRCA2 genes in 32 breast and/or ovarian cancer Spanish families
por: Osorio, A, et al.
Publicado: (2000)

Large genomic rearrangements in BRCA1 and BRCA2 genes in breast and ovarian cancer families in Poland
por: Bielecka, Helena, et al.
Publicado: (2012)

Large genomic rearrangements in BRCA1 and BRCA2 genes in breast and ovarian cancer families in Poland
por: Bielecka, Helena, et al.
Publicado: (2012)

Sequence Variants of BRCA1 and BRCA2 Genes in Four Iranian Families with Breast and Ovarian Cancer
por: Keshavarzi, F, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_bpcg41p9cc4dg7k2vricrtfoci