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Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer?

The human p53 tumor suppressor gene TP53 is mutated at a high frequency in sporadic breast cancer, and Li-Fraumeni syndrome patients who carry germline mutations in one TP53 allele have a high incidence of breast cancer. In the 10 years since the first knockout of the mouse p53 tumor suppressor gene...

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Detalles Bibliográficos
Autores principales: Blackburn, Anneke C, Jerry, D Joseph
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138724/
https://www.ncbi.nlm.nih.gov/pubmed/12052252
http://dx.doi.org/10.1186/bcr427