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From lymphocytes to sharks: V(D)J recombinase moves to the germline
The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recombination system that carries out these DNA rearrangements may thus be a significant evolutio...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138851/ https://www.ncbi.nlm.nih.gov/pubmed/11178236 |
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author | Roth, David B |
author_facet | Roth, David B |
author_sort | Roth, David B |
collection | PubMed |
description | The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recombination system that carries out these DNA rearrangements may thus be a significant evolutionary force, perhaps not limited to rearrangements at antigen-receptor loci. |
format | Text |
id | pubmed-138851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1388512003-03-03 From lymphocytes to sharks: V(D)J recombinase moves to the germline Roth, David B Genome Biol Minireview The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recombination system that carries out these DNA rearrangements may thus be a significant evolutionary force, perhaps not limited to rearrangements at antigen-receptor loci. BioMed Central 2000 2000-08-02 /pmc/articles/PMC138851/ /pubmed/11178236 Text en Copyright © 2000 GenomeBiology.com |
spellingShingle | Minireview Roth, David B From lymphocytes to sharks: V(D)J recombinase moves to the germline |
title | From lymphocytes to sharks: V(D)J recombinase moves to the germline |
title_full | From lymphocytes to sharks: V(D)J recombinase moves to the germline |
title_fullStr | From lymphocytes to sharks: V(D)J recombinase moves to the germline |
title_full_unstemmed | From lymphocytes to sharks: V(D)J recombinase moves to the germline |
title_short | From lymphocytes to sharks: V(D)J recombinase moves to the germline |
title_sort | from lymphocytes to sharks: v(d)j recombinase moves to the germline |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138851/ https://www.ncbi.nlm.nih.gov/pubmed/11178236 |
work_keys_str_mv | AT rothdavidb fromlymphocytestosharksvdjrecombinasemovestothegermline |