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From lymphocytes to sharks: V(D)J recombinase moves to the germline

The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recombination system that carries out these DNA rearrangements may thus be a significant evolutio...

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Detalles Bibliográficos
Autor principal: Roth, David B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138851/
https://www.ncbi.nlm.nih.gov/pubmed/11178236
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author Roth, David B
author_facet Roth, David B
author_sort Roth, David B
collection PubMed
description The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recombination system that carries out these DNA rearrangements may thus be a significant evolutionary force, perhaps not limited to rearrangements at antigen-receptor loci.
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spelling pubmed-1388512003-03-03 From lymphocytes to sharks: V(D)J recombinase moves to the germline Roth, David B Genome Biol Minireview The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recombination system that carries out these DNA rearrangements may thus be a significant evolutionary force, perhaps not limited to rearrangements at antigen-receptor loci. BioMed Central 2000 2000-08-02 /pmc/articles/PMC138851/ /pubmed/11178236 Text en Copyright © 2000 GenomeBiology.com
spellingShingle Minireview
Roth, David B
From lymphocytes to sharks: V(D)J recombinase moves to the germline
title From lymphocytes to sharks: V(D)J recombinase moves to the germline
title_full From lymphocytes to sharks: V(D)J recombinase moves to the germline
title_fullStr From lymphocytes to sharks: V(D)J recombinase moves to the germline
title_full_unstemmed From lymphocytes to sharks: V(D)J recombinase moves to the germline
title_short From lymphocytes to sharks: V(D)J recombinase moves to the germline
title_sort from lymphocytes to sharks: v(d)j recombinase moves to the germline
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138851/
https://www.ncbi.nlm.nih.gov/pubmed/11178236
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