Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway

When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA caps are key effectors of the fate of spliced mRNAs and may regulate whether mRNAs contain...

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Detalles Bibliográficos
Autores principales: Schell, Thomas, Kulozik, Andreas E, Hentze, Matthias W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139025/
https://www.ncbi.nlm.nih.gov/pubmed/11897029
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author Schell, Thomas
Kulozik, Andreas E
Hentze, Matthias W
author_facet Schell, Thomas
Kulozik, Andreas E
Hentze, Matthias W
author_sort Schell, Thomas
collection PubMed
description When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA caps are key effectors of the fate of spliced mRNAs and may regulate whether mRNAs containing premature stop codons are degraded.
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spelling pubmed-1390252003-03-03 Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway Schell, Thomas Kulozik, Andreas E Hentze, Matthias W Genome Biol Minireview When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA caps are key effectors of the fate of spliced mRNAs and may regulate whether mRNAs containing premature stop codons are degraded. BioMed Central 2002 2002-02-26 /pmc/articles/PMC139025/ /pubmed/11897029 Text en Copyright © 2002 BioMed Central Ltd
spellingShingle Minireview
Schell, Thomas
Kulozik, Andreas E
Hentze, Matthias W
Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway
title Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway
title_full Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway
title_fullStr Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway
title_full_unstemmed Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway
title_short Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway
title_sort integration of splicing, transport and translation to achieve mrna quality control by the nonsense-mediated decay pathway
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139025/
https://www.ncbi.nlm.nih.gov/pubmed/11897029
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AT hentzematthiasw integrationofsplicingtransportandtranslationtoachievemrnaqualitycontrolbythenonsensemediateddecaypathway

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