Computational approaches for predicting the biological effect of p53 missense mutations: a comparison of three sequence analysis based methods

Prediction of the biological effect of missense substitutions has become important because they are often observed in known or candidate disease susceptibility genes. In this paper, we carried out a 3-step analysis of 1514 missense substitutions in the DNA-binding domain (DBD) of TP53, the most freq...

Descripción completa

Detalles Bibliográficos
Autores principales: Mathe, Ewy, Olivier, Magali, Kato, Shunsuke, Ishioka, Chikashi, Hainaut, Pierre, Tavtigian, Sean V.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1390679/
https://www.ncbi.nlm.nih.gov/pubmed/16522644
http://dx.doi.org/10.1093/nar/gkj518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1390679/
https://www.ncbi.nlm.nih.gov/pubmed/16522644
http://dx.doi.org/10.1093/nar/gkj518

Ejemplares similares