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Macrophage metalloelastase (MMP-12) deficiency does not alter bleomycin-induced pulmonary fibrosis in mice

BACKGROUND: Pulmonary fibrosis is characterized by excessive deposition of extracellular matrix in the interstitium resulting in respiratory failure. The role of remodeling mediators such as metalloproteinases (MMPs) and their inhibitors (TIMPs) in the fibrogenic process remains misunderstood. In pa...

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Detalles Bibliográficos
Autores principales: Manoury, Boris, Nenan, Soazig, Guenon, Isabelle, Boichot, Elisabeth, Planquois, Jean-Michel, Bertrand, Claude P, Lagente, Vincent
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1397817/
https://www.ncbi.nlm.nih.gov/pubmed/16504062
http://dx.doi.org/10.1186/1476-9255-3-2