Ligand-induced estrogen receptor α degradation by the proteasome: new actors?

In this perspective we consider new aspects of ligand-induced estrogen receptor α (ERα) degradation. What are the possible roles of CSN5/Jab1 and the CSN complex in this process? We compare hormone (estrogen) or pure antagonist (fulvestrant) induced degradation of ERα and review the effects of kinas...

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Detalles Bibliográficos
Autores principales: Calligé, Mathilde, Richard-Foy, Hélène
Formato: Texto
Lenguaje:English
Publicado: The Nuclear Receptor Signaling Atlas 2006
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402212/
https://www.ncbi.nlm.nih.gov/pubmed/16604167
http://dx.doi.org/10.1621/nrs.04004
Descripción
Sumario:In this perspective we consider new aspects of ligand-induced estrogen receptor α (ERα) degradation. What are the possible roles of CSN5/Jab1 and the CSN complex in this process? We compare hormone (estrogen) or pure antagonist (fulvestrant) induced degradation of ERα and review the effects of kinase-inhibitors and CRM1-dependent nuclear export on ERα degradation and transcription activation. A model for ERα action integrating these new actors is proposed and the relation between hormone-induced ERα degradation and transcription-activation is discussed.

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