Ligand-induced estrogen receptor α degradation by the proteasome: new actors?

In this perspective we consider new aspects of ligand-induced estrogen receptor α (ERα) degradation. What are the possible roles of CSN5/Jab1 and the CSN complex in this process? We compare hormone (estrogen) or pure antagonist (fulvestrant) induced degradation of ERα and review the effects of kinas...

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Detalles Bibliográficos
Autores principales: Calligé, Mathilde, Richard-Foy, Hélène
Formato: Texto
Lenguaje:English
Publicado: The Nuclear Receptor Signaling Atlas 2006
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402212/
https://www.ncbi.nlm.nih.gov/pubmed/16604167
http://dx.doi.org/10.1621/nrs.04004
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author Calligé, Mathilde
Richard-Foy, Hélène
author_facet Calligé, Mathilde
Richard-Foy, Hélène
author_sort Calligé, Mathilde
collection PubMed
description In this perspective we consider new aspects of ligand-induced estrogen receptor α (ERα) degradation. What are the possible roles of CSN5/Jab1 and the CSN complex in this process? We compare hormone (estrogen) or pure antagonist (fulvestrant) induced degradation of ERα and review the effects of kinase-inhibitors and CRM1-dependent nuclear export on ERα degradation and transcription activation. A model for ERα action integrating these new actors is proposed and the relation between hormone-induced ERα degradation and transcription-activation is discussed.
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spelling pubmed-14022122006-04-06 Ligand-induced estrogen receptor α degradation by the proteasome: new actors? Calligé, Mathilde Richard-Foy, Hélène Nucl Recept Signal Perspective In this perspective we consider new aspects of ligand-induced estrogen receptor α (ERα) degradation. What are the possible roles of CSN5/Jab1 and the CSN complex in this process? We compare hormone (estrogen) or pure antagonist (fulvestrant) induced degradation of ERα and review the effects of kinase-inhibitors and CRM1-dependent nuclear export on ERα degradation and transcription activation. A model for ERα action integrating these new actors is proposed and the relation between hormone-induced ERα degradation and transcription-activation is discussed. The Nuclear Receptor Signaling Atlas 2006-02-08 /pmc/articles/PMC1402212/ /pubmed/16604167 http://dx.doi.org/10.1621/nrs.04004 Text en Copyright © 2006, Callige and Richard-Foy This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspective
Calligé, Mathilde
Richard-Foy, Hélène
Ligand-induced estrogen receptor α degradation by the proteasome: new actors?
title Ligand-induced estrogen receptor α degradation by the proteasome: new actors?
title_full Ligand-induced estrogen receptor α degradation by the proteasome: new actors?
title_fullStr Ligand-induced estrogen receptor α degradation by the proteasome: new actors?
title_full_unstemmed Ligand-induced estrogen receptor α degradation by the proteasome: new actors?
title_short Ligand-induced estrogen receptor α degradation by the proteasome: new actors?
title_sort ligand-induced estrogen receptor α degradation by the proteasome: new actors?
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402212/
https://www.ncbi.nlm.nih.gov/pubmed/16604167
http://dx.doi.org/10.1621/nrs.04004
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AT richardfoyhelene ligandinducedestrogenreceptoradegradationbytheproteasomenewactors

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