Linking lipids, Alzheimer's and LXRs?

Deposition of the β-amyloid (Aβ) peptide is thought to underlie development of Alzheimer's disease (AD). This pathological linkage has spurred considerable interest in therapeutic strategies to reduce Aβ production. It is becoming increasingly clear that altered cholesterol homeostasis can modu...

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Detalles Bibliográficos
Autores principales: Patel, Nilay V., Forman, Barry Marc
Formato: Texto
Lenguaje:English
Publicado: The Nuclear Receptor Signaling Atlas 2004
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402230/
https://www.ncbi.nlm.nih.gov/pubmed/16604185
http://dx.doi.org/10.1621/nrs.02001
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author Patel, Nilay V.
Forman, Barry Marc
author_facet Patel, Nilay V.
Forman, Barry Marc
author_sort Patel, Nilay V.
collection PubMed
description Deposition of the β-amyloid (Aβ) peptide is thought to underlie development of Alzheimer's disease (AD). This pathological linkage has spurred considerable interest in therapeutic strategies to reduce Aβ production. It is becoming increasingly clear that altered cholesterol homeostasis can modulate Aβ production and/or accumulation. In this review, we discuss the molecular pathology of AD, the cholesterol connection and recent data suggesting that the oxysterol receptor, liver X receptor LXR (NR1H2 and NR1H3), may modulate these events.
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spelling pubmed-14022302006-04-06 Linking lipids, Alzheimer's and LXRs? Patel, Nilay V. Forman, Barry Marc Nucl Recept Signal Review Deposition of the β-amyloid (Aβ) peptide is thought to underlie development of Alzheimer's disease (AD). This pathological linkage has spurred considerable interest in therapeutic strategies to reduce Aβ production. It is becoming increasingly clear that altered cholesterol homeostasis can modulate Aβ production and/or accumulation. In this review, we discuss the molecular pathology of AD, the cholesterol connection and recent data suggesting that the oxysterol receptor, liver X receptor LXR (NR1H2 and NR1H3), may modulate these events. The Nuclear Receptor Signaling Atlas 2004-04-05 /pmc/articles/PMC1402230/ /pubmed/16604185 http://dx.doi.org/10.1621/nrs.02001 Text en Copyright © 2004, Patel and Forman. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Patel, Nilay V.
Forman, Barry Marc
Linking lipids, Alzheimer's and LXRs?
title Linking lipids, Alzheimer's and LXRs?
title_full Linking lipids, Alzheimer's and LXRs?
title_fullStr Linking lipids, Alzheimer's and LXRs?
title_full_unstemmed Linking lipids, Alzheimer's and LXRs?
title_short Linking lipids, Alzheimer's and LXRs?
title_sort linking lipids, alzheimer's and lxrs?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402230/
https://www.ncbi.nlm.nih.gov/pubmed/16604185
http://dx.doi.org/10.1621/nrs.02001
work_keys_str_mv AT patelnilayv linkinglipidsalzheimersandlxrs
AT formanbarrymarc linkinglipidsalzheimersandlxrs

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