Evidence for conservation and selection of upstream open reading frames suggests probable encoding of bioactive peptides

BACKGROUND: Approximately 40% of mammalian mRNA sequences contain AUG trinucleotides upstream of the main coding sequence, with a quarter of these AUGs demarcating open reading frames of 20 or more codons. In order to investigate whether these open reading frames may encode functional peptides, we h...

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Detalles Bibliográficos
Autores principales: Crowe, Mark L, Wang, Xue-Qing, Rothnagel, Joseph A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402274/
https://www.ncbi.nlm.nih.gov/pubmed/16438715
http://dx.doi.org/10.1186/1471-2164-7-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402274/
https://www.ncbi.nlm.nih.gov/pubmed/16438715
http://dx.doi.org/10.1186/1471-2164-7-16

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