Mutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection

BACKGROUND: The mutation spectra of the TP53 gene and other tumor suppressors contain multiple hotspots, i.e., sites of non-random, frequent mutation in tumors and/or the germline. The origin of the hotspots remains unclear, the general view being that they represent highly mutable nucleotide contex...

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Detalles Bibliográficos
Autores principales: Glazko, Galina V, Babenko, Vladimir N, Koonin, Eugene V, Rogozin, Igor B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1403748/
https://www.ncbi.nlm.nih.gov/pubmed/16542006
http://dx.doi.org/10.1186/1745-6150-1-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1403748/
https://www.ncbi.nlm.nih.gov/pubmed/16542006
http://dx.doi.org/10.1186/1745-6150-1-4

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