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Mutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection
BACKGROUND: The mutation spectra of the TP53 gene and other tumor suppressors contain multiple hotspots, i.e., sites of non-random, frequent mutation in tumors and/or the germline. The origin of the hotspots remains unclear, the general view being that they represent highly mutable nucleotide contex...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1403748/ https://www.ncbi.nlm.nih.gov/pubmed/16542006 http://dx.doi.org/10.1186/1745-6150-1-4 |