A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

Lens epithelium-derived growth factor p75 (LEDGF/p75) is a DNA-binding, transcriptional co-activator that participates in HIV-1 integration site targeting. Using complementary approaches, we determined the mechanisms of LEDGF/p75 DNA-binding in vitro and chromatin-association in living cells. The bi...

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Detalles Bibliográficos
Autores principales: Turlure, Fanny, Maertens, Goedele, Rahman, Shaila, Cherepanov, Peter, Engelman, Alan
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1405818/
https://www.ncbi.nlm.nih.gov/pubmed/16549878
http://dx.doi.org/10.1093/nar/gkl052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1405818/
https://www.ncbi.nlm.nih.gov/pubmed/16549878
http://dx.doi.org/10.1093/nar/gkl052

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