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Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase
Human 8-oxoguanine-DNA glycosylase (OGG1) is the major enzyme for repairing 8-oxoguanine (8-oxoG), a mutagenic guanine base lesion produced by reactive oxygen species (ROS). A frequently occurring OGG1 polymorphism in human populations results in the substitution of serine 326 for cysteine (S326C)....
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1405821/ https://www.ncbi.nlm.nih.gov/pubmed/16549874 http://dx.doi.org/10.1093/nar/gkl060 |