Synthesis and characterization of oligonucleotides containing 2′-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction

Endonuclease III (Endo III) is a base excision repair enzyme that recognizes oxidized pyrimidine bases including thymine glycol. This enzyme is a glycosylase/lyase and forms a Schiff base-type intermediate with the substrate after the damaged base is removed. To investigate the mechanism of its subs...

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Detalles Bibliográficos
Autores principales: Doi, Yusuke, Katafuchi, Atsushi, Fujiwara, Yoshie, Hitomi, Kenichi, Tainer, John A., Ide, Hiroshi, Iwai, Shigenori
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1409675/
https://www.ncbi.nlm.nih.gov/pubmed/16547199
http://dx.doi.org/10.1093/nar/gkl061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1409675/
https://www.ncbi.nlm.nih.gov/pubmed/16547199
http://dx.doi.org/10.1093/nar/gkl061

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