Cargando…

Synthesis and characterization of oligonucleotides containing 2′-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction

Endonuclease III (Endo III) is a base excision repair enzyme that recognizes oxidized pyrimidine bases including thymine glycol. This enzyme is a glycosylase/lyase and forms a Schiff base-type intermediate with the substrate after the damaged base is removed. To investigate the mechanism of its subs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Doi, Yusuke, Katafuchi, Atsushi, Fujiwara, Yoshie, Hitomi, Kenichi, Tainer, John A., Ide, Hiroshi, Iwai, Shigenori
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1409675/ https://www.ncbi.nlm.nih.gov/pubmed/16547199 http://dx.doi.org/10.1093/nar/gkl061

Ejemplares similares

Preferential formation of (5S,6R)-thymine glycol for oligodeoxyribonucleotide synthesis and analysis of drug binding to thymine glycol-containing DNA
por: Shimizu, Tatsuhiko, et al.
Publicado: (2006)

AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation
por: Dornfeld, Ken, et al.
Publicado: (2005)

Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana
por: Kashiwagi, Sayo, et al.
Publicado: (2010)

Human endonuclease V is a ribonuclease specific for inosine-containing RNA
por: Morita, Yoko, et al.
Publicado: (2013)

Arabidopsis thaliana endonuclease V is a ribonuclease specific for inosine-containing single-stranded RNA
por: Endo, Megumi, et al.
Publicado: (2021)

Sequencing by ligation variation with endonuclease V digestion and deoxyinosine-containing query oligonucleotides
por: Ho, Antoine, et al.
Publicado: (2011)

Directional cloning of DNA fragments using deoxyinosine-containing oligonucleotides and endonuclease V
por: Baumann, Tobias, et al.
Publicado: (2013)

Tandem mass spectrometric sequence characterization of synthetic thymidine‐rich oligonucleotides
por: Abdullah, A. M., et al.
Publicado: (2022)

Chemical synthesis of oligodeoxyribonucleotides containing the Dewar valence isomer of the (6–4) photoproduct and their use in (6–4) photolyase studies
por: Yamamoto, Junpei, et al.
Publicado: (2006)

Is Thymidine Glycol Containing DNA a Substrate of E. coli DNA Mismatch Repair System?
por: Perevozchikova, Svetlana A., et al.
Publicado: (2014)

Correction: Is Thymidine Glycol Containing DNA a Substrate of E. coli DNA Mismatch Repair System?
Publicado: (2015)

A strongly pairing fifth base: oligonucleotides with a C-nucleoside replacing thymidine
por: Walter, Tanja J, et al.
Publicado: (2018)

Biochemical properties and base excision repair complex formation of apurinic/apyrimidinic endonuclease from Pyrococcus furiosus
por: Kiyonari, Shinichi, et al.
Publicado: (2009)

Synthesis and applications of theranostic oligonucleotides carrying multiple fluorine atoms
por: Metelev, Valeriy G., et al.
Publicado: (2020)

Analysis of Structural Flexibility of Damaged DNA Using Thiol-Tethered Oligonucleotide Duplexes
por: Fujita, Masashi, et al.
Publicado: (2015)

Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3′-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease
por: Yamamoto, Junpei, et al.
Publicado: (2016)

Organo-fluorine chemistry III
por: O'Hagan, David
Publicado: (2013)

Thymidine Phosphorylase Gene Expression in Stage III Colorectal Cancer
por: Lindskog, Elinor B., et al.
Publicado: (2012)

Improved Metal-Free Approach for the Synthesis of Protected Thiol Containing Thymidine Nucleoside Phosphoramidite and Its Application for the Synthesis of Ligatable Oligonucleotide Conjugates
por: Kupihár, Zoltán, et al.
Publicado: (2023)

Polymerase-Endonuclease Amplification Reaction (PEAR) for Large-Scale Enzymatic Production of Antisense Oligonucleotides
por: Wang, Xiaolong, et al.
Publicado: (2010)

Poly-Thymidine Oligonucleotides Mediate Activation of Murine Glial Cells Primarily Through TLR7, Not TLR8
por: Du, Min, et al.
Publicado: (2011)

UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions
por: Meulenbroek, Elisabeth M., et al.
Publicado: (2013)

Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides
por: Østergaard, Michael E., et al.
Publicado: (2017)

Depletion of plasma thymidine results in growth retardation and mitochondrial myopathy in mice overexpressing human thymidine phosphorylase
por: Harada, Naomoto, et al.
Publicado: (2023)

Novel Fluorinated Poly (Lactic-Co-Glycolic acid) (PLGA) and Polyethylene Glycol (PEG) Nanoparticles for Monitoring and Imaging in Osteoarthritis
por: Zerrillo, Luana, et al.
Publicado: (2021)

Structural Basis for the Propagation of Homing Endonuclease-Associated Inteins
por: Beyer, Hannes M., et al.
Publicado: (2022)

Chlorella virus pyrimidine dimer glycosylase and Escherichia coli endonucleases IV and V have incision activity on 2,2,4-triamino-5(2H)-oxazolone
por: Kino, Katsuhito, et al.
Publicado: (2015)

THYMIDINE DEGRADATION PRODUCTS IN PLANT TISSUES LABELED WITH TRITIATED THYMIDINE
por: Takats, S. T., et al.
Publicado: (1963)

THYMIDINE TRIPHOSPHATE SYNTHESIS IN TETRAHYMENA : I. Studies on Thymidine Kinase
por: Shoup, G. D., et al.
Publicado: (1966)

INDUCIBILITY OF THYMIDINE KINASE BY THYMIDINE AS A FUNCTION OF INTERPHASE STAGE
por: Hotta, Yasuo, et al.
Publicado: (1965)

Preparation of 5′-O-(1-Thiotriphosphate)-Modified Oligonucleotides Using Polymerase-Endonuclease Amplification Reaction (PEAR)
por: Li, Biao, et al.
Publicado: (2013)

A study on endonuclease BspD6I and its stimulus-responsive switching by modified oligonucleotides
por: Abrosimova, Liudmila A., et al.
Publicado: (2018)

Pathways of thymidine hypermodification
por: Lee, Yan-Jiun, et al.
Publicado: (2021)

Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides
por: Lau, J P, et al.
Publicado: (2004)

Involvement of Hydrogen Peroxide in Safingol-Induced Endonuclease G-Mediated Apoptosis of Squamous Cell Carcinoma Cells
por: Hamada, Masakazu, et al.
Publicado: (2014)

Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways
por: Wei, Qiong, et al.
Publicado: (2015)

Toward quantification of hypoxia using fluorinated Eu(II/III)-containing ratiometric probes
por: Subasinghe, S. A. Amali S., et al.
Publicado: (2023)

Topical delivery of DNA oligonucleotide to induce p53 generation in the skin via thymidine dinucleotide (pTT)-encapsulated liposomal carrier
por: Fang, Yi-Ping
Publicado: (2011)

Semi-batch synthesis of colloidal spheres with fluorinated cores and varying grafts of poly(ethylene glycol)
por: Jonsson, G. Kristin, et al.
Publicado: (2017)

Oligonucleotides conjugated with short chemically defined polyethylene glycol chains are efficient antisense agents
por: Shokrzadeh, Nasrin, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_qd7a5hc5pk9bo3t17lh757rfg0