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A new pooling strategy for high-throughput screening: the Shifted Transversal Design

BACKGROUND: In binary high-throughput screening projects where the goal is the identification of low-frequency events, beyond the obvious issue of efficiency, false positives and false negatives are a major concern. Pooling constitutes a natural solution: it reduces the number of tests, while provid...

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Detalles Bibliográficos
Autor principal: Thierry-Mieg, Nicolas
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1409803/
https://www.ncbi.nlm.nih.gov/pubmed/16423300
http://dx.doi.org/10.1186/1471-2105-7-28