Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism

INTRODUCTION: Dehydroepiandrosterone (DHEA), an adrenal 17-ketosteroid, is a precursor of testosterone and 17β-estradiol. Studies have shown that DHEA inhibits carcinogenesis in mammary gland and prostate as well as other organs, a process that is not hormone dependent. Little is known about the mol...

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Detalles Bibliográficos
Autores principales: Shilkaitis, Anne, Green, Albert, Punj, Vasu, Steele, Vernon, Lubet, Ronald, Christov, Konstantin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1410767/
https://www.ncbi.nlm.nih.gov/pubmed/16457693
http://dx.doi.org/10.1186/bcr1350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1410767/
https://www.ncbi.nlm.nih.gov/pubmed/16457693
http://dx.doi.org/10.1186/bcr1350

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