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Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
Poly (ADP-ribose) polymerase (PARP-1), ATM and DNA-dependent protein kinase (DNA-PK) are all involved in responding to DNA damage to activate pathways responsible for cellular survival. Here, we demonstrate that PARP-1(−/−) cells are sensitive to the ATM inhibitor KU55933 and conversely that AT cell...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1410911/ https://www.ncbi.nlm.nih.gov/pubmed/16556909 http://dx.doi.org/10.1093/nar/gkl108 |