Testing Electrostatic Complementarity in Enzyme Catalysis: Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

A longstanding proposal in enzymology is that enzymes are electrostatically and geometrically complementary to the transition states of the reactions they catalyze and that this complementarity contributes to catalysis. Experimental evaluation of this contribution, however, has been difficult. We ha...

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Detalles Bibliográficos
Autores principales: Kraut, Daniel A, Sigala, Paul A, Pybus, Brandon, Liu, Corey W, Ringe, Dagmar, Petsko, Gregory A, Herschlag, Daniel
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413570/
https://www.ncbi.nlm.nih.gov/pubmed/16602823
http://dx.doi.org/10.1371/journal.pbio.0040099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413570/
https://www.ncbi.nlm.nih.gov/pubmed/16602823
http://dx.doi.org/10.1371/journal.pbio.0040099

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