Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis

There is evidence that multiple sclerosis (MS) may associated with cognitive impairment in 25 to 40% of cases. The gene encoding myeloperoxidase (MPO) is involved in molecular pathways leading to β-amyloid deposition. We investigated a functional biallelic (G/A) polymorphism in the promoter region (...

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Autores principales: Manna, I, Valentino, P, La Russa, A, Condino, F, Nisticò, R, Liguori, M, Clodomiro, A, Andreoli, V, Pirritano, D, Cittadella, R, Quattrone, A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420327/
https://www.ncbi.nlm.nih.gov/pubmed/16504169
http://dx.doi.org/10.1186/1477-5751-5-3
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author Manna, I
Valentino, P
La Russa, A
Condino, F
Nisticò, R
Liguori, M
Clodomiro, A
Andreoli, V
Pirritano, D
Cittadella, R
Quattrone, A
author_facet Manna, I
Valentino, P
La Russa, A
Condino, F
Nisticò, R
Liguori, M
Clodomiro, A
Andreoli, V
Pirritano, D
Cittadella, R
Quattrone, A
author_sort Manna, I
collection PubMed
description There is evidence that multiple sclerosis (MS) may associated with cognitive impairment in 25 to 40% of cases. The gene encoding myeloperoxidase (MPO) is involved in molecular pathways leading to β-amyloid deposition. We investigated a functional biallelic (G/A) polymorphism in the promoter region (-463) of the MPO gene in 465 patients affected by MS, divided into 204 cognitively normal and 261 impaired. We did not find significant differences in allele or genotype distributions between impaired and preserved MS patients. Our findings suggest that MPO polymorphism is not a risk factor for cognitive impairment in MS.
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spelling pubmed-14203272006-03-30 Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis Manna, I Valentino, P La Russa, A Condino, F Nisticò, R Liguori, M Clodomiro, A Andreoli, V Pirritano, D Cittadella, R Quattrone, A J Negat Results Biomed Brief Report There is evidence that multiple sclerosis (MS) may associated with cognitive impairment in 25 to 40% of cases. The gene encoding myeloperoxidase (MPO) is involved in molecular pathways leading to β-amyloid deposition. We investigated a functional biallelic (G/A) polymorphism in the promoter region (-463) of the MPO gene in 465 patients affected by MS, divided into 204 cognitively normal and 261 impaired. We did not find significant differences in allele or genotype distributions between impaired and preserved MS patients. Our findings suggest that MPO polymorphism is not a risk factor for cognitive impairment in MS. BioMed Central 2006-02-27 /pmc/articles/PMC1420327/ /pubmed/16504169 http://dx.doi.org/10.1186/1477-5751-5-3 Text en Copyright © 2006 Manna et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Manna, I
Valentino, P
La Russa, A
Condino, F
Nisticò, R
Liguori, M
Clodomiro, A
Andreoli, V
Pirritano, D
Cittadella, R
Quattrone, A
Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis
title Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis
title_full Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis
title_fullStr Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis
title_full_unstemmed Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis
title_short Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis
title_sort genetic variation in the myeloperoxidase gene and cognitive impairment in multiple sclerosis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420327/
https://www.ncbi.nlm.nih.gov/pubmed/16504169
http://dx.doi.org/10.1186/1477-5751-5-3
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