Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation

The class III histone deactylase (HDAC), SIRT1, has cancer relevance because it regulates lifespan in multiple organisms, down-regulates p53 function through deacetylation, and is linked to polycomb gene silencing in Drosophila. However, it has not been reported to mediate heterochromatin formation...

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Detalles Bibliográficos
Autores principales: Pruitt, Kevin, Zinn, Rebekah L, Ohm, Joyce E, McGarvey, Kelly M, Kang, Sung-Hae L, Watkins, D. Neil, Herman, James G, Baylin, Stephen B
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420676/
https://www.ncbi.nlm.nih.gov/pubmed/16596166
http://dx.doi.org/10.1371/journal.pgen.0020040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420676/
https://www.ncbi.nlm.nih.gov/pubmed/16596166
http://dx.doi.org/10.1371/journal.pgen.0020040

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