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DNA deformability changes of single base pair mutants within CDE binding sites in S. Cerevisiae centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries

BACKGROUND: The centromeres in yeast (S. cerevisiae) are organized by short DNA sequences (125 bp) on each chromosome consisting of 2 conserved elements: CDEI and CDEIII spaced by a CDEII region. CDEI and CDEIII are critical sequence specific protein binding sites necessary for correct centromere fo...

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Detalles Bibliográficos
Autores principales: Hennemuth, Brad, Marx, Kenneth A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1434758/
https://www.ncbi.nlm.nih.gov/pubmed/16542422
http://dx.doi.org/10.1186/1471-2199-7-12