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Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells
BACKGROUND: Nitrogen-containing bisphosphonates (N-BPs) have been designed to inhibit osteoclast-mediated bone resorption. However, it is now accepted that part of their anti-tumor activities is related to interference with the mevalonate pathway. METHODS: We investigated the effects of zoledronic a...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1434759/ https://www.ncbi.nlm.nih.gov/pubmed/16539721 http://dx.doi.org/10.1186/1471-2407-6-60 |