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Novel synthesis of O(6)-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O(6)-methylguanine DNA methyltransferase (MGMT)
The human DNA repair protein O(6)-methylguanine DNA methyltransferase (MGMT) dealkylates mutagenic O(6)-alkylguanine lesions within DNA in an irreversible reaction which results in inactivation of the protein. MGMT also provides resistance of tumours to alkylating agents used in cancer chemotherapy...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435717/ https://www.ncbi.nlm.nih.gov/pubmed/16609128 http://dx.doi.org/10.1093/nar/gkl117 |