Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions

BACKGROUND: DNA duplex sequences that can be targets for triplex formation are highly over-represented in the human genome, especially in regulatory regions. RESULTS: Here we studied using bioinformatics tools several properties of triplex target sequences in an attempt to determine those that make...

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Detalles Bibliográficos
Autores principales: Goñi, Josep Ramon, Vaquerizas, Juan Manuel, Dopazo, Joaquin, Orozco, Modesto
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435886/
https://www.ncbi.nlm.nih.gov/pubmed/16566817
http://dx.doi.org/10.1186/1471-2164-7-63
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author Goñi, Josep Ramon
Vaquerizas, Juan Manuel
Dopazo, Joaquin
Orozco, Modesto
author_facet Goñi, Josep Ramon
Vaquerizas, Juan Manuel
Dopazo, Joaquin
Orozco, Modesto
author_sort Goñi, Josep Ramon
collection PubMed
description BACKGROUND: DNA duplex sequences that can be targets for triplex formation are highly over-represented in the human genome, especially in regulatory regions. RESULTS: Here we studied using bioinformatics tools several properties of triplex target sequences in an attempt to determine those that make these sequences so special in the genome. CONCLUSION: Our results strongly suggest that the unique physical properties of these sequences make them particularly suitable as "separators" between protein-recognition sites in the promoter region.
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spelling pubmed-14358862006-04-21 Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions Goñi, Josep Ramon Vaquerizas, Juan Manuel Dopazo, Joaquin Orozco, Modesto BMC Genomics Research Article BACKGROUND: DNA duplex sequences that can be targets for triplex formation are highly over-represented in the human genome, especially in regulatory regions. RESULTS: Here we studied using bioinformatics tools several properties of triplex target sequences in an attempt to determine those that make these sequences so special in the genome. CONCLUSION: Our results strongly suggest that the unique physical properties of these sequences make them particularly suitable as "separators" between protein-recognition sites in the promoter region. BioMed Central 2006-03-27 /pmc/articles/PMC1435886/ /pubmed/16566817 http://dx.doi.org/10.1186/1471-2164-7-63 Text en Copyright © 2006 Goñi et al; licensee BioMed Central Ltd.
spellingShingle Research Article
Goñi, Josep Ramon
Vaquerizas, Juan Manuel
Dopazo, Joaquin
Orozco, Modesto
Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions
title Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions
title_full Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions
title_fullStr Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions
title_full_unstemmed Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions
title_short Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions
title_sort exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435886/
https://www.ncbi.nlm.nih.gov/pubmed/16566817
http://dx.doi.org/10.1186/1471-2164-7-63
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