Cargando…

Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease

BACKGROUND: Accumulating evidence suggests that inflammation plays an important role in the progression of Parkinson's disease (PD). Among many inflammatory factors found in the PD brain, cyclooxygenase (COX), specifically the inducible isoform, COX-2, is believed to be a critical enzyme in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vijitruth, Rattanavijit, Liu, Mei, Choi, Dong-Young, Nguyen, Xuan V, Hunter, Randy L, Bing, Guoying
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440849/ https://www.ncbi.nlm.nih.gov/pubmed/16566823 http://dx.doi.org/10.1186/1742-2094-3-6

Ejemplares similares

DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson’s disease
por: Kinugawa, Kiyoka, et al.
Publicado: (2013)

Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons
por: Hong, J, et al.
Publicado: (2015)

Quercetin Protects against MPP(+)/MPTP-Induced Dopaminergic Neuron Death in Parkinson's Disease by Inhibiting Ferroptosis
por: Lin, Zhi-Hao, et al.
Publicado: (2022)

Herbal medicine (Hepad) prevents dopaminergic neuronal death in the rat MPTP model of Parkinson’s disease
por: Kim, Dong Hee, et al.
Publicado: (2019)

Microglial cGAS drives neuroinflammation in the MPTP mouse models of Parkinson's disease
por: Ma, Chunmei, et al.
Publicado: (2023)

Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid—Lesioned Parkinson’s Disease Models
por: He, Xuan, et al.
Publicado: (2019)

Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease
por: García-Domínguez, Irene, et al.
Publicado: (2018)

Brain-specific NRSF deficiency aggravates dopaminergic neurodegeneration and impairs neurogenesis in the MPTP mouse model of Parkinson’s disease
por: Huang, Dongping, et al.
Publicado: (2019)

Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance
por: Lu, Ming, et al.
Publicado: (2016)

Impact of intravenous immunoglobulin on the dopaminergic system and immune response in the acute MPTP mouse model of Parkinson’s disease
por: St-Amour, Isabelle, et al.
Publicado: (2012)

MicroRNA-212-5p Prevents Dopaminergic Neuron Death by Inhibiting SIRT2 in MPTP-Induced Mouse Model of Parkinson’s Disease
por: Sun, Sifan, et al.
Publicado: (2018)

Depletion of microglia augments the dopaminergic neurotoxicity of MPTP
por: Yang, Xiaoxia, et al.
Publicado: (2018)

Synuclein Proteins in MPTP-Induced Death of Substantia Nigra Pars Compacta Dopaminergic Neurons
por: Goloborshcheva, Valeria V., et al.
Publicado: (2022)

Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson’s disease
por: Peng, Qinyu, et al.
Publicado: (2022)

RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson’s Disease Mouse Models
por: Kim, Do-Yeon, et al.
Publicado: (2023)

MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson's Disease
por: Chung, Young Cheul, et al.
Publicado: (2013)

PEP-1-HO-1 prevents MPTP-induced degeneration of dopaminergic neurons in a Parkinson’s disease mouse model
por: Youn, Jong Kyu, et al.
Publicado: (2014)

Cerebroventricular Microinjections of MPTP on Adult Zebrafish Induces Dopaminergic Neuronal Death, Mitochondrial Fragmentation, and Sensorimotor Impairments
por: Kalyn, Michael, et al.
Publicado: (2021)

PET Analysis of Dopaminergic Neurodegeneration in Relation to Immobility in the MPTP-Treated Common Marmoset, a Model for Parkinson’s Disease
por: Ando, Kiyoshi, et al.
Publicado: (2012)

Tat-Fused Recombinant Human SAG Prevents Dopaminergic Neurodegeneration in a MPTP-Induced Parkinson’s Disease Model
por: Sohn, Eun Jeong, et al.
Publicado: (2014)

Neuroprotective Effects of Tetramethylpyrazine against Dopaminergic Neuron Injury in a Rat Model of Parkinson's Disease Induced by MPTP
por: Lu, Chen, et al.
Publicado: (2014)

The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson’s disease
por: Rabaneda-Lombarte, Neus, et al.
Publicado: (2021)

Cdk5 Inhibitory Peptide Prevents Loss of Dopaminergic Neurons and Alleviates Behavioral Changes in an MPTP Induced Parkinson’s Disease Mouse Model
por: He, Rongni, et al.
Publicado: (2018)

Lobeline shows protective effects against MPTP-induced dopaminergic neuron death and attenuates behavior deficits in animals
por: LI, CHAO-YUE, et al.
Publicado: (2014)

Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice
por: Xu, Shuang-Feng, et al.
Publicado: (2018)

Vitexin protects dopaminergic neurons in MPTP-induced Parkinson’s disease through PI3K/Akt signaling pathway
por: Hu, Ming, et al.
Publicado: (2018)

Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson’s Disease Induced by MPTP
por: Viveros-Paredes, Juan M., et al.
Publicado: (2017)

Functional Crosstalk between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson's Disease
por: Wi, Rayul, et al.
Publicado: (2020)

Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway
por: Jing, Haoran, et al.
Publicado: (2017)

Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson's Disease
por: Huang, Dongping, et al.
Publicado: (2017)

Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson’s disease
por: DAI, TING-LI, et al.
Publicado: (2014)

Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease
por: Qiao, Chen, et al.
Publicado: (2018)

Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson’s Disease
por: Okuyama, Satoshi, et al.
Publicado: (2016)

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease
por: Noelker, Carmen, et al.
Publicado: (2013)

Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson’s disease model induced by MPTP
por: Filichia, Emily, et al.
Publicado: (2016)

Validity of the MPTP-Treated Mouse as a Model for Parkinson’s Disease
por: Klemann, Cornelius J. H. M., et al.
Publicado: (2015)

Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson’s Disease Mice
por: Yan, Aijuan, et al.
Publicado: (2019)

The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration
por: Drouin-Ouellet, Janelle, et al.
Publicado: (2011)

TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone
por: Zheng, Cong, et al.
Publicado: (2018)

Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson’s Disease
por: Marchetti, Bianca
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nnbkak8rn7qegdgr903j6revdb