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Conformational Changes in Protein Loops and Helices Induced by Post-Translational Phosphorylation
Post-translational phosphorylation is a ubiquitous mechanism for modulating protein activity and protein-protein interactions. In this work, we examine how phosphorylation can modulate the conformation of a protein by changing the energy landscape. We present a molecular mechanics method in which we...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440919/ https://www.ncbi.nlm.nih.gov/pubmed/16628247 http://dx.doi.org/10.1371/journal.pcbi.0020032 |