Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides

Human topoisomerase II (topo II) is the cellular target for a number of widely used antitumor agents, such as etoposide (VP16). These agents ‘poison’ the enzyme and induce it to generate DNA breaks that are lethal to the cell. Topo II-targeted drugs show a limited sequence preference, triggering dou...

Descripción completa

Detalles Bibliográficos
Autores principales: Duca, Maria, Guianvarc'h, Dominique, Oussedik, Kahina, Halby, Ludovic, Garbesi, Anna, Dauzonne, Daniel, Monneret, Claude, Osheroff, Neil, Giovannangeli, Carine, Arimondo, Paola B.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447649/
https://www.ncbi.nlm.nih.gov/pubmed/16598074
http://dx.doi.org/10.1093/nar/gkl126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447649/
https://www.ncbi.nlm.nih.gov/pubmed/16598074
http://dx.doi.org/10.1093/nar/gkl126

Ejemplares similares