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Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides

Human topoisomerase II (topo II) is the cellular target for a number of widely used antitumor agents, such as etoposide (VP16). These agents ‘poison’ the enzyme and induce it to generate DNA breaks that are lethal to the cell. Topo II-targeted drugs show a limited sequence preference, triggering dou...

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Detalles Bibliográficos
Autores principales:	Duca, Maria, Guianvarc'h, Dominique, Oussedik, Kahina, Halby, Ludovic, Garbesi, Anna, Dauzonne, Daniel, Monneret, Claude, Osheroff, Neil, Giovannangeli, Carine, Arimondo, Paola B.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447649/ https://www.ncbi.nlm.nih.gov/pubmed/16598074 http://dx.doi.org/10.1093/nar/gkl126

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