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Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol
BACKGROUND: A recent crystal structure of monastrol in a ternary complex with the kinesin Eg5 motor domain highlights a novel, induced-fit drug binding site at atomic resolution. Mutational obliteration of the monastrol binding site results in a monastrol-resistant, but otherwise catalytically activ...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448180/ https://www.ncbi.nlm.nih.gov/pubmed/16504166 http://dx.doi.org/10.1186/1472-6769-6-2 |