Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol

BACKGROUND: A recent crystal structure of monastrol in a ternary complex with the kinesin Eg5 motor domain highlights a novel, induced-fit drug binding site at atomic resolution. Mutational obliteration of the monastrol binding site results in a monastrol-resistant, but otherwise catalytically activ...

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Detalles Bibliográficos
Autores principales: Maliga, Zoltan, Mitchison, Timothy J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448180/
https://www.ncbi.nlm.nih.gov/pubmed/16504166
http://dx.doi.org/10.1186/1472-6769-6-2