Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures

We have used a combination of simulated annealing (SA), molecular dynamics (MD) and locally enhanced sampling (LES) methods in order to predict the favourable topologies and loop conformations of dimeric DNA quadruplexes with T2 or T3 loops. This follows on from our previous MD simulation studies on...

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Detalles Bibliográficos
Autores principales: Hazel, Pascale, Parkinson, Gary N, Neidle, Stephen
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449907/
https://www.ncbi.nlm.nih.gov/pubmed/16641317
http://dx.doi.org/10.1093/nar/gkl182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449907/
https://www.ncbi.nlm.nih.gov/pubmed/16641317
http://dx.doi.org/10.1093/nar/gkl182

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